• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    TOOL AND DEVICE FOR TOTAL CIRCUMFERENTAL INSERTION FOR AN IMPLANT IN AN EYE SCHLEMM CHANNEL. A device (1,9,12,15,16) is provided to allow the placement of an implant in the total circumference of an eye's Schlemm canal. The device comprises a flexible elongated solid element (2.10) with a proximal end and a distal tip that transmits light such as one or more strands of an optical fiber. The device is characterized by selected mechanical characteristics (3, ll, 16, 17) to allow advancement within the Schlemm channel. The fiber optic element transmits light from a proximal to distal connector to provide an illuminated tip that can be viewed in the sclera when the device is advanced along the Schlemm channel.
    公开号:BR112012030160B1
    申请号:R112012030160-8
    申请日:2011-05-25
    公开日:2020-11-03
    发明作者:Ronald K. Yamamoto；Stanley R. Conston
    申请人:Iscience Interventional Corporation；
    IPC主号:
    专利说明:

    PRIORITY CLAIM
    [0001] Priority is claimed in US Provisional Order No. Ser. No. 61 / 348,915, filed on May 27, 2010, the disclosure of which is hereby incorporated by reference in its entirety for all purposes. FIELD OF THE INVENTION
    [0002] The present invention relates to devices for inserting flexible elongated implants into the total circumference or a segment of the circumference of the Schlemm canal of an eye. BACKGROUND OF THE INVENTION
    [0003] Glaucoma is a condition of eye disease in which high intraocular pressure (IPO) is created by blocking the drainage mechanism for the aqueous fluid produced in the anterior portion of the eye. Such conditions are usually treated by topical medications in the form of eye drops, but they can result in surgical treatment becoming ineffective or if patient complication is an issue. Traditional glaucoma surgery, known as a trabeculectomy, involves dissection of the eye and the formation of a fistula from the anterior chamber to the subconjunctive space. Trabeculectomy is associated with a high incidence of postoperative complications.
    [0004] Recently developed surgical treatments for glaucoma have focused on restoring the natural drainage system, including the trabecular meshwork and Schlemm's canal. The use of an implant that is placed around the entire circumference of the Schlemm canal to treat glaucoma is described in US Patent Application Publication No. 20060195187, published on August 31, 2006 in the names of Stegmann et al. The device of the present invention provides new surgical instruments that allow the placement of an implant in the total circumference or segment of the circumference of the Schlemm canal, without penetrating the intraocular space. SUMMARY OF THE INVENTION
    [0005] The present invention provides devices that allow the placement of an implant in the total circumference or in a segment of the circumference of the Schlemm canal of an eye. One embodiment of a device according to the invention comprises a flexible elongated solid element with a proximal end and a distal tip that transmits light, such as one or more strands of an optical fiber. The elongated solid element has appropriate dimensions and appropriate mechanical characteristics to allow advancement within the Schlemm channel. The fiber optic element transmits light from a proximal connector to the distal tip of the elongated solid element to provide an illuminated tip that can be seen in the sclera by the surgeon when the device is advanced along the Schlemm channel. This feature allows the surgeon to guide the device and prevent it from advancing into the wrong tissue spaces. The device is provided with fixation characteristics at the distal tip, which allow the attachment of an implant to be pulled into a Schlemm channel by the device. Modalities of such characteristics may comprise an eyelet, a groove, a loop of material, or a circumferential slit in the distal tip or a bulbous tip of greater diameter than the elongated solid element of the device, to which an end of a circumferential implant can be attached. . By solid it is understood that there is a cross section of solid material in the element so that there is no cavity extending along a longitudinal axis within the element.
    [0006] In a cross section through the eye, the Schlemm channel presents a narrow flat channel arranged at approximately 45 ° to the ocular axis with a cross-sectional dimension greater than approximately 200 to 250 microns. The circumference of the Schlemm canal in a human eye is typically 36 mm. The elongated solid element of the device of the present invention is sized to fit within the Schlemm channel and has sufficient flexibility to adapt to the curvature of the channel during advancement. A rounded or atraumatic distal tip further aids in the device's ability to advance the channel. The elongated solid element will have sufficient rigidity to be advanced along the Schlemm channel cavity by applying force to one or both ends of the elongated solid element without collapsing the elongated solid element in the channel. The elongated solid element will also have sufficient flexibility to bend to follow the Schlemm channel tract while the element is advanced inward or retracted from the Schlemm channel without causing undue bleeding or tissue damage. Typically, a measurable flexural stiffness of the elongated solid element in the range of 2.2 x E-12 to 3.0 x E-10 kN * m2 is useful. The elongated solid element can be made of metal, synthetic polymers such as plastics, natural fibers or polymers, or combinations thereof.
    [0007] A method is provided by the invention for total circumferential insertion for an implant in a Schlemm canal of the eye comprising the steps of:
    [0008] a) advancing fully circumferentially in the Schlemm channel a tool by moving the tool in a first direction through the Schlemm channel, the tool comprising a flexible elongated solid element with the distal and proximal ends, the distal and / or proximal ends comprising a mechanical element for fixing the implant, and a distal and / or proximal light transmitting element for positioning the distal and / or proximal end of the tool during placement and advancement, whereby the distal end is exposed when exiting the Schlemm canal ;
    [0009] b) affix the proximal end of an implant to the exposed distal end of the tool, the implant comprising a second elongated element with distal and proximal ends and having a dimension sufficient for insertion into the canal and sufficient length for total circumferential insertion by 360 ° on a Schlemm channel;
    [00010] c) remove the tool and implant affixed through the Schlemm channel in the reverse direction of the first direction, whereby the tool is removed from the Schlemm channel, the implant is completely circumferentially positioned inside the Schlemm channel, and the proximal end attached to the implant is exposed when exiting the Schlemm canal; and
    [00011] d) detach the implant from the tool. After detaching the implant from the tool, the distal and proximal ends of the implant can be attached to each other directly or to a gripping element, or to the tissue. BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 shows a device comprising a twisted optical fiber forming a terminal loop at the distal end. Figure 2 shows a device comprising an optical fiber with an atraumatic tip. Figure 3 shows a device comprising an optical fiber comprising a split end, joined at an atraumatic tip. Figure 4 shows a device comprising a single optical fiber twisted back on itself at the distal end to form a loop. Figure 5 shows a device comprising a single optical fiber with a rounded atraumatic tip that incorporates a circumferential slit. Figure 6 shows a device after advancing into the total length of the Schlemm channel. DESCRIPTION OF SPECIFIC MODALITIES
    [00012] To use the device, a surgical access is created to expose the Schlemm canal by dissecting the overlying sclera. The device is placed in the surgical ostia of the canal and manually advanced. The light coming from the distal tip can be observed to ensure that the device is in the proper position in the Schlemm channel and continued to be advanced until the distal tip of the device passes through the entire channel and out through the surgical access site. A lubricating friction reducer or hydrophilic coating on the device can be incorporated to reduce the force required to advance the device within the Schlemm channel.
    [00013] The elongated solid element of the device has appropriate dimensions and appropriate mechanical characteristics to allow advancement within the Schlemm channel. An elongated solid element is mechanically preferred over an elongated hollow element that can bend or collapse due to axial loading or bending forces during use. The elongated member preferably has a length of at least 36 mm so that it can be inserted through the entire circumference of the Schlemm canal and expose the distal tip to the surgeon in order to affix an implant. The implant preferably has distal and proximal ends and a length and diameter sufficient for insertion into the Schlemm channel for circumferential insertion into the channel. The elongated solid element with attached implant can then be removed back through the Schlemm channel until the attached end (proximal end) of the implant is exposed to the surgeon. The device can then be detached from the implant. The proximal and distal ends of the implant can be attached to each other directly or to a gripping element, or to the tissue, at the surgeon's option. Similarly, the device can be used to position a suture length on the circumference of the Schlemm canal. One end of the suture can be attached to the proximal end of the implant and the opposite end of the suture used to pull the implant for positioning in the canal.
    [00014] The elongated solid element of the device will have typical dimensions of a diameter in the range of about 10-300 microns and a length of at least about 36 mm. Implants will typically have diameters similar to or smaller than the elongated solid element of the device.
    [00015] In one embodiment, the device comprises a length of flexible optical fiber, folded over itself, then twisted to form an elongated solid element with a loop forming the distal tip. The loop provides a curve in the optical fiber where the critical angle of incidence for total internal reflection is exceeded, and acts as a light source. Since there is no cut end of the optical fiber at the distal end, the loop also serves as an atraumatic tip and an eyelet for attaching an implant that can be pulled into a Schlemm channel.
    [00016] The twisted fiber configuration of the fiber optic comprising the elongated solid element provides several ways to configure the bending properties of the device. The material composition and diameter of the optical fiber can also be selected to provide the desired amount of flexural rigidity of the elongated element. In addition, the twisting step of the configuration can be adjusted to further configure flexural stiffness and axial compressive stiffness. In order to allow placement in the total circumference of the Schlemm channel, it is preferred that the flexural stiffness is as low as possible to minimize flexibility. An external flexible tubular sleeve or sleeve can be placed over the device up to the distal tip to further adapt the mechanical properties and protect the fiber optics.
    [00017] In one embodiment, the implant to be placed inside the Schlemm channel can have an end that comprises a filament or a connector that can be threaded through an eyelet at the distal end of the device. The eyelet may be formed by a loop of twisted fiber, a single optical fiber with a hole formed at the distal end, a single optical fiber divided and assembled at the distal end, or a single optical fiber with the distal end formed back into a loop. The implant can be attached to the eyelet after the device has passed through the circumference of the canal and then pulled into place within the Schlemm canal. Alternatively, the implant can be attached to the eyelet at the distal end before the device is placed in a Schlemm channel and pulled into place while the device is passing through the channel circumference. Similarly, the end of the implant can be tied to a device that has a groove, loop of material or bulbous tip positioned at the distal end to allow secure attachment of the implant. When the bulbous tip is used, it is preferable that the diameter of the tip is at least 50% greater than the thickness of the device's cross section to avoid unwanted detachment by sliding a suture, thread, filament, etc. attached to the device. Although not intended to be limited to the following, the types of implants contemplated to be inserted into a Schlemm channel using a device according to the invention include, sutures, metal wires, wires, cords, coils, stents and fibers, elastic or not elastic.
    [00018] In another embodiment, the fixation characteristics of the device can be formed at the proximal end. After advancing the device across the total circumference of the Schlemm channel, an end of the implant can be attached to the proximal end and the device continued to be advanced or pulled into the channel to place the implant along the total circumference. Alternatively, the implant can be advanced or pulled into a desired segment of the canal and released. The release can be facilitated by affixing the implant to the device with a length of suture or filament that can be cut or untied when the implant is properly positioned within the Schlemm canal.
    [00019] In another embodiment, the device may comprise an optical fiber with a rounded atraumatic tip and features for attaching an end of an implant to either the distal end or the proximal end of the device. The optical fiber can comprise a flexible polymer surrounded by a second polymer in a tubular configuration to improve the optical or mechanical properties of the optical fiber.
    [00020] The optical fiber is coupled to a proximal connector that provides connection to a light source to provide a light entry to the distal end of the device. The distal optical fiber of the device that is sized to fit within the Schlemm channel can be optically coupled to a larger optical fiber diameter through a connector element. Alternatively, the distal optical fiber can be coupled directly to the proximal connector. In another embodiment, the optical fiber can be directly attached to the light source without a connector.
    [00021] Figure 1 shows a detailed view of a device 1 comprising a flexible optical fiber 2 that has been twisted to form a loop 3 at the distal end for attaching an implant device 4. The proximal ends of the optical fiber 5 are placed inside of a connector 6. The proximal ends of the optical fiber are optically coupled to the connector to the distal end of a second optical fiber 7 that ends in a proximal connector 8 for attachment to a light source.
    [00022] Figure 2 shows a detailed view of a device 9 comprising a single flexible optical fiber 10 in which the distal tip is formed into a rounded atraumatic tip 11 with an implanted device 4 attached. The proximal end of the optical fiber 5 is placed in a connector 6. The proximal end of the optical fiber is optically coupled in the connector to the distal end of a second optical fiber 7 that ends in a proximal connector 8 for attachment to a light source.
    [00023] Figure 3 shows a detailed view of a device 12 comprising a single flexible optical fiber 10 in which the distal segment has been divided and joined 14 for attaching an implant device 4. The distal tip is formed into a rounded atraumatic tip 11. The proximal end of the optical fiber 5 is placed inside a connector 6. The proximal end of the optical fiber is optically coupled in the connector to the distal end of a second optical fiber 7 that ends in a proximal connector 8 for attachment to a source of lighting.
    [00024] Figure 4 shows a detailed view of a device 15 comprising a single flexible optical fiber 10 in which the distal end is formed back on itself in a loop 16 for attaching an implant device 4. The proximal end of the optical fiber 5 is placed inside a connector 6. The proximal end of the optical fiber is optically coupled in the connector to the distal end of a second optical fiber 7 which ends in a proximal connector 8 for attachment to a light source.
    [00025] Figure 5 shows a detailed view of a device 16 comprising a single flexible optical fiber 10 in which the distal end is formed into a rounded atraumatic tip 11 which incorporates a circumferential slot 17 over which an implant device (not shown) ) can be displayed. The proximal end of the optical fiber 18 is coupled directly to a proximal connector 8 for attachment to a light source.
    [00026] Figure 6 shows a schematic view of the device 1 of figure 1, which has been advanced around the Schlemm channel 19 into an eye 20, so that the distal loop 3 has left the channel and is in position for display of an implant, so that the implant can be placed into the canal.
    [00027] The following examples are presented for the purpose of illustration and are not intended to limit the invention in any way. EXAMPLES Example 1
    [00028] Devices according to the invention have been manufactured. Two prototypes were built using 70 micron (0.0028 inch) and 100 micron (0.004 inch) outside diameter plastic optical fibers (Biogeral Inc). The fibers comprised a polystyrene (PS) core, within a tubular layer of polymethylmethacrylate (PMMA) to act as a coating. The inner core and coating were contained within a tubular polyvinylidene fluoride (PVDF) shell. Fibers were cut to a length of 120 mm (4.7 inches) and the cut ends were aligned collinearly and joined together with UV curing adhesive (4305, Loctite Corp.) forming a teardrop shaped loop. The joined ends were mounted on a rotating mandrel and the linked end was placed on a 0.5 mm (0.02 inch) diameter shaft. As the rotating mandrel was rotated, UV curing adhesive with a durometry of 50 Shore D (201 CTH, Dymax Inc) was applied to the twisted fibers and cured in incremental lengths. The twist was continued until the loop end was approximately 5 mm (0.2 inch) long.
    [00029] The proximal ends were placed inside a polycarbonate tube with UV adhesive (4305, Loctite Corp.). The resulting device was approximately 50 mm (2 inches) long. A larger plastic optical fiber (ES KA ™ fiber, Mitsubishi Rayon Co LTD) was used to connect the prototype device to a laser diode optical fiber light source (iLumin ™, iScience Interventional Corp.). The fiber was composed of a 250 micron (0.01 inch) diameter core of (poly) methyl methacrylate (PMMA), a fluorinated polymer coating and a polyethylene shell for a total external diameter of 1 mm (0.04 inch). The larger fiber wrapper is removed to expose a shorter core length. The core was inserted into the polycarbonate connector until it rests against the cut ends of the twisted device fibers, and then adhesive-bonded in place. The proximal end of the ESKA ™ fiber ended in a connector designed for the iLumin ™ connector. The connector was connected to the illuminator and a light source turned on. Clear light was seen at the distal end of the loop of the twisted fibers. Example 2
    [00030] Another device according to the invention has been manufactured. An ESKA ™ plastic optical fiber with a 250 micron core, as described in example 1, was cut to a length of 500 mm (20 inches). The casing was removed from the core for a length of 50 mm (2 inches). The distal tip of the nucleus was divided with a razor blade. A 125 micron (0.005 inch) metal wire was inserted into the split to maintain the opening, while the cut distal ends were adhesive-bonded back together with UV curing adhesive (4305, Loctite Corp). Additional adhesive was applied to the distal tip to create a 340 micron (0.013 inch) diameter non-spherical tip. The proximal end was joined to another length of the ESKA ™ plastic fiber with a connector for the illuminator, as in example 1. The device was connected to the illuminator and a bright light was seen at the distal end. Example 3
    [00031] Additional devices according to the invention have been manufactured. Devices comprising 70 micron and 100 micron plastic optical fibers, as described in example 1, were used. UV curing adhesive (4305, Loctite Inc.) was used to form an olive-shaped tip at the end of each fiber that was cut to a length of 50 mm (2 inches). The bulbous tips were nominally 325 microns (0.013 inches) in diameter. The fibers were glued end to end to a short length of bare ESKA ™ fiber using the UV curing adhesive. The ESKA ™ fiber was inserted into a polycarbonate connector attached to another length of ESKA ™ fiber wrapped with a connector as in example 1. When connected to the light source (iLumin ™, iScience Interventional Corp.), the devices displayed a clear light at the distal ends. Example 4
    [00032] The devices according to example 1, example 2 and example 3 were tested on human cadaver eyes. The eyes were prepared using a standard two-tab scleral cut, as used in non-penetrating glaucoma surgery, to expose the Schlemm canal. The first test device was performed using the 100 micron fiber loop of example 1. The loop end was inserted into a Schlemm channel and advanced around the channel until the loop left the surgical site. A 9-0 polypropylene suture (Prolene, Ethicon Inc) was inserted through the loop end and then the device was removed through the channel, successfully pulling the suture into the channel. The second test was performed with the 70 micron fiber loop from example 1. The same method was used and the prototype successfully provided the suture into the canal. It was noted that the smaller diameter fiber was a little more difficult to push around the canal, but the advancement and then the placement of the suture implant was still successful. The third test used the device of example 2. The larger and more rigid prototype was more difficult to move around the Schlemm channel, but it was successful in transiting the full length. The fourth and fifth tests were performed with the prototype devices of example 3. Each device was flexible enough to be successfully advanced around the Schlemm channel to the distal tips that emerged from the ostia of the channel. A 10-0 polypropylene suture (Prolene, Ethicon Inc) was tied to the distal ends of the devices and successfully removed back through the channel. In each trial, the illuminated tip of the device was clearly seen through the scleral tissues and allowed visual tracking of the device moving around the Schlemm channel. Example 5
    [00033] Another device according to the invention has been manufactured. The device comprised a 70 micron plastic optical fiber as described in example 1. UV curing adhesive, as described in example 3, was used to form a 175 micron diameter bulbous tip. The fiber was glued into a polycarbonate and ES KA ™ fiber connector as in example 1, and exhibited clear light at the distal end when connected to a light source. A human cadaver eye was prepared and a surgical cut was made to expose the Schlemm canal. The 70 micron tipped fiber was inserted into the ostia of the channel and advanced 360 ° around the channel. An illuminated tip was observed through the sclera when the fiber was advanced. Example 6
    [00034] Plastic optical fibers with diameters of 70 and 100 microns, described in example 1, were evaluated using a mechanical test device (Instron) with a 5 Newton load cell to determine its bending flexural stiffness by 3 points . Bending stiffness at bending was calculated from the Instron output. The bending tangent modulus, EB, was determined using a modified Flexion Test method from ASTM D790-07. Due to the very small diameter of the fiber samples, the test method was modified through the use of smaller supports and a loading spigot of 2.4 mm (0.095 inch) in diameter and a smaller support span of 5.08 mm (0.200). Instron's EB result was then multiplied by the 2nd moment of inertia, I, to obtain flexural stiffness, E * I. The moment, I, was calculated using I = π * r2 / 4, where r is equal to the fiber radius.
    [00035] Small diameter optical fibers, when individually tested on Instron, were below the detection limit for the load cell. To determine EB for the individual fibers, two fibers were adhesive bonded together in parallel with a low UV curing adhesive (3321, Loctite Inc). The resulting tangent module was divided by two to obtain EB.
    [00036] Twisted pairs of 100 micron fiber, similar to those in example 1, were tested to determine their flexural stiffness in the same way. Two fibers were twisted together and then adhesive-bonded as with the parallel fibers. Two twisted pairs of different pitch were prepared, one with a 2 mm (0.08 inch) pitch and the other with a 5 mm (0.2 inch) pitch. Table 1 shows the tested devices and their corresponding flexural stiffnesses, devices with a flexural stiffness of 3.0 x 1010 kNm2 or less are sufficiently flexible to allow complete circumferential advancement of the device in the Schlemm channel.Table 1: Optical Fibers Plastic - Properties of
    Example 7
    [00037] An experiment was carried out to evaluate the requirements for the diameter of the bulbous tip of a cannula in order to attach a small diameter suture that can act as an implant or can be attached to a separate implant device to effect the placement of the implant within the Schlemm canal. Samples of model device tips were prepared by applying a small amount of adhesive (Loctite 4305, Loctite Corp) to the end of a 200 um (0.008 inch) 304 stainless steel wire. The adhesive was carefully applied to create smooth bulbous tips of varying diameter. A metal wire without a bulbous tip was also tested as a control. Prolene 10-0 (Ethicon, Inc) suture segments with a diameter of 30 µm (0.0012 inch) were tied tightly to the wire samples and the suture loop was positioned just below the tip of the wire under test. An Instron mechanical test device with a 5 Newton load cell was used to measure the load required to pull the sutures from the metal wires at a crosshead speed of 100 mm / min. Five runs were performed for each metallic wire / tip sample and the results were averaged. The results are shown in table 2 below. The "Break / Traction" column indicates how many sutures have broken along the fiber without being pulled out of the tip. The column "% of suture" indicates the relative size of the bulbous tip radius in relation to the 30 micron suture, that is, the 230 micron tip diameter represents a tip that extends radially from the metallic wire with 1/2 of the suture diameter. To attach the suture, the tip diameter must be dimensioned to be larger than the cannula diameter where it presents an interface to the bulbous tip by more than 50% of the suture diameter. Table 2: Results of Ponta Bulbosa Suture Fastening Test
    权利要求:
    Claims (15)
    [0001]
    1. Tool for total circumferential insertion of an implant into the Schlemm channel (19) of the eye (20), said tool comprising a flexible elongated solid element with a distal and proximal end, said distal and / or proximal ends comprising an element mechanical for affixing said implant, characterized by the fact that an optical fiber light transmitting element (2) folded over itself to form a loop (3) at the distal and / or proximal end of said flexible elongated solid element by means of of which the loop (3) provides an atraumatic distal and / or proximal end and provides a fold in the fiber optic element (2) so that the critical angle of incidence for internal reflection is exceeded to produce a light source element for locate the distal and / or proximal end of said tool during placement and advancement.
    [0002]
    2. Tool according to claim 1, characterized by the fact that said elongated solid element provides total circumferential insertion by 360 ° of said element in the Schlemm channel (19).
    [0003]
    3. Tool according to claim 1, characterized by the fact that said tool with an implant attached to said distal end provides total circumferential insertion by 360 ° of said implant in the Schlemm channel (19).
    [0004]
    4. Tool according to claim 1, characterized by the fact that it also comprises a lubricant coating.
    [0005]
    5. Tool according to claim 1, characterized by the fact that said loop (3) forms an eyelet serving as said mechanical element to affix said implant to said elongated solid element.
    [0006]
    6. Tool according to claim 1, characterized by the fact that said mechanical element comprises an end of said optical fiber which is divided and assembled (2).
    [0007]
    7. Tool according to claim 1, characterized by the fact that said mechanical element comprises a hole in one end of said optical fiber (2).
    [0008]
    8. Tool according to claim 1, characterized by the fact that said elongated element is wrapped at least in part with a flexible tubular sleeve.
    [0009]
    9. Tool according to claim 1, characterized by the fact that the elongated solid element has a flexural stiffness in the range of 2.2 x E-12 to 3.0 x E-10 kN * m2.
    [0010]
    10. Tool according to claim 1, characterized in that the elongated solid element comprises a plurality of optical fibers (2).
    [0011]
    11. Tool according to claim 1, characterized by the fact that said tool comprises a polymer.
    [0012]
    12. Device for total circumferential insertion of an implant in the Schlemm channel (19) of the eye (20), characterized by the fact that it comprises: a tool as defined in claim 1, in which the implant is affixed to said tool, said implant comprising a second elongated element with the distal and proximal ends and having a dimension sufficient for insertion into the channel (19) and sufficient length for total circumferential insertion by 360 ° in a Schlemm channel (19).
    [0013]
    13. Device according to claim 12, characterized in that the elongated solid element has a flexural stiffness in the range of 2.2 x E-12 to 3.0 x E-10 kN * m2.
    [0014]
    14. Device according to claim 12, characterized in that said implant comprises a filament.
    [0015]
    Device according to claim 14, characterized in that said filament comprises non-elastic or elastic material.
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    法律状态:
    2018-12-26| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|
    2019-09-17| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|
    2020-05-12| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2020-09-24| B11D| Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time|
    2020-10-27| B11N| Dismissal: publication cancelled [chapter 11.14 patent gazette]|Free format text: ANULADA A PUBLICACAO CODIGO 11.4 NA RPI NO 2594 DE 24/09/2020 POR TER SIDO INDEVIDA. |
    2020-11-03| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 25/05/2011, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    US34891510P| true| 2010-05-27|2010-05-27|
    US61/348,915|2010-05-27|
    PCT/US2011/037882|WO2011150045A1|2010-05-27|2011-05-25|Device for placing circumferential implant in schlemm's canal|
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